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KMID : 1146920210510010061
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Journal of Pharmaceutical Investigation
2021 Volume.51 No. 1 p.61 ~ p.73
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Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer
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Khan Iftikhar
Yousaf Sakib
Najlah Mohammad
Ahmed Waqar
Elhissi Abdelbary
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Abstract
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Purpose: The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer.
Methods: Proliposome powders were prepared by the slurry method and sorbitol or mannitol carbohydrate carrier were used in a 1:10 and 1:15 w/w lipid phase to carrier ratio. Beclometasone dipropionate (BDP; 2 mol%) was incorporated in the lipid phase. Proliposome powders were compressed into tablets, and liposomes were generated from proliposome powders or tablets within the nebulizer reservoir for subsequent aerosolization.
Results: Comparatively, shorter sputtering times were reported for the tablet formulations (??
Conclusion: Overall, this study showed that proliposome tablets could be disintegrated within a Pari-LC Sprint nebulizer to generate inhalable aerosol, with high drug output and hence can be manufactured on large scale to overcome the storage problems associated with powder formulations.
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KEYWORD
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Liposome, Proliposome, Jet-nebulizer, Two-stage impinger, Beclometasone dipropionate, Tablets
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